CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.

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It is of interest to 145501. Product Type. Monoclonal Antibody. Alternate Names. 4-1BB, TNFRSF9 , CD137 Antigen, T-Cell Antigen ILA. Isotype.

Cd137 4-1bb

This antibody reacts with Human samples. Supplied as 100 Tests purified antibody (5 µL/Test). 4-1BB (CD137) Antibodies for Flow Cytometry CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.

Similar to its mouse counterpart, human Recombinant HEK293 cell line expressing a full length human CD137 (4-1BB) ( NM_001561). The NF-ĸB luciferase reporter construct is stably integrated into Recombinant Monoclonal Antibody. Detection of Human 4-1BB/TNFRSF9/ CD137 antibody by Western Blot.

(CD137) som en målmolekyl för immunterapi och behandling av cancer. Alligator har två utvecklingsprogram där 4-1BB är målmolekyl, dels

CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting 4-1BB, also known as CD137 and ILA (induced by lymphocyte activation), is a TNF receptor superfamily member and has been designated TNFRSF9.

Signaleringsdomäner från en mängd olika co-stimulatoriska molekyler har framgångsrikt testats, inklusive CD28, CD27, CD134 (OX40) och CD137 (4-1BB).

CD137. When this molecule, also called 4-1BB, is bound by CD137 ligand, the result is T-cell proliferation.

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Signaling via 4-1BB upregulates survival genes, enhances cell division, induces cytokine production, and prevents activation-induced cell death in T cells.

Similar to its mouse counterpart, human Recombinant HEK293 cell line expressing a full length human CD137 (4-1BB) ( NM_001561). The NF-ĸB luciferase reporter construct is stably integrated into Recombinant Monoclonal Antibody. Detection of Human 4-1BB/TNFRSF9/ CD137 antibody by Western Blot.
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The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- κB, c-Jun and p38 …

4-1BB functions in the development and activation of multiple immune cells (1). Mature human 4-1BB consists of a 163 amino acid (aa) extracellular domain (ECD) with four TNFR cysteine-rich repeats, a 27 aa transmembrane 4‑1BB/TNFRSF9/CD137 in Rat Splenocytes. 4-1BB/TNFRSF9/CD137 was detected in immersion fixed rat splenocytes treated with calcium ionomycin and PMA using Goat Anti-Rat 4-1BB/TNFRSF9/ CD137 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF9029) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary … TNFRSF9 / 4-1BB / CD137 is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses.